Golden RF Microneedling (also called Gold RF Microneedling) creates microchannels in the skin that significantly enhance the transdermal absorption of active products. When combined with targeted ingredients, it achieves a multi-dimensional effect of treatment + repair + functional enhancement. Based on clinical studies and ingredient mechanisms, here’s a detailed classification of recommended combinations and their outcomes.
I. Immediate Repair Agents (0–72 Hours Post-Treatment)
(1) Hyaluronic Acid (HA)
- Function: Deep hydration + wound healing, relieves post-treatment dryness/tightness, improves skin plumpness.
- Evidence: Combination improved skin radiance and smoothness by 87.5%, and significantly shortened erythema resolution time.
- Clinical Study:
- Title: Application of Golden RF Microneedling Combined with Topical Hyaluronic Acid and Epidermal Growth Factor in Facial Rejuvenation
- Authors: Chen Min, Xu Jinqian
- Published: May 15, 2019, Chinese Journal of Aesthetic Medicine (Issue 5)
- Summary:
- Objective: Evaluate efficacy and safety of Golden RF Microneedling with HA and EGF for facial rejuvenation.
- Methods: 32 patients with facial aging underwent RF microneedling, followed by topical HA + EGF 3–5 times/day for 7 days. Outcomes were observed before treatment, 1 month, and 3 months after.
- Results: After 3 treatments, patients showed tighter facial contours, reduced wrinkles, no adverse reactions (e.g., hyperpigmentation or scarring). Efficacy: 87.5% significant improvement, 12.5% effective, 0% ineffective (total 100%).
- Conclusion: RF microneedling with HA + EGF is safe and effective for facial rejuvenation.
(2) Collagen Dressing / Serum
- Function: Barrier repair + reduces pigmentation, especially suitable for sensitive skin or high-energy settings.
- Results: Skin elasticity improved 35% within 1 month, though effect diminished by 3 months (long-term anti-aging still requires additional therapy).
- Clinical Study:
- Title: Clinical Application of Golden RF Microneedling Combined with Collagen Dressing in Facial Rejuvenation
- Authors: Sun Yepei, Tang Xiang, Li Yuanqing, Jie Shiyue
- Published: 2022, China Medical Aesthetics, Vol.12, Issue 2: 29–33
- DOI: 10.19593/j.issn.2095-0721.2022.12.008
- Summary:
- Objective: Assess efficacy of RF microneedling + collagen dressing.
- Methods: 58 patients divided into combo group vs. single treatment group.
- Results: At 1 month, combo group showed significantly better skin improvement (P<0.05). At 3 months, differences were no longer significant. Adverse reactions were fewer in the combo group.
- Conclusion: Collagen dressing enhances 1-month results and reduces post-op reactions, though long-term benefits require additional strategies.
(3) Growth Factors (EGF/bFGF)
- Function: Accelerates barrier repair, reduces pigmentation and infection risks.
- Data: In acne scar patients, scab formation shortened to 3.08 days (vs. 5.97 days in control), with 40% fewer adverse reactions.
- Clinical Study:
- Title: Clinical Effect of Golden RF Microneedling Combined with Epidermal Growth Factor in Acne Scar Treatment
- Source: Medical report (WeChat channel: Pan Xiaoshuo)
- Summary:
- Methods: 70 acne scar patients divided into control (RF + erythromycin ointment) and experimental (RF + EGF gel). Both treated twice.
- Results:
- Total efficacy: 94.3% (EGF group) vs. 74.3% (control).
- Scab and healing time significantly shorter in EGF group.
- Lower VSS scar scores and complication rate (28.6% vs. 68.6%).
- Patient satisfaction higher (91.4% vs. 68.6%).
- Conclusion: RF microneedling + EGF improves acne scars, reduces complications, shortens recovery.
II. Bioactive Agents (Intraoperative or Post-Treatment Enhancement)
(1) PRP (Platelet-Rich Plasma)
- Function: Autologous growth factors (PDGF, VEGF, etc.) stimulate collagen regeneration, fill acne pits, improve firmness.
- Protocol: Immediate PRP application post-microneedling reduced ECCA scar score by 53%, with 91.9% efficacy, superior to roller microneedling + PRP.
- Clinical Study:
- Title: Efficacy of Golden RF Microneedling Combined with PRP in Atrophic Acne Scars
- Institution: Henan University First Affiliated Hospital, Dept. of Dermatology
- Results:
- ECCA score significantly lower vs. control.
- Total efficacy: 91.9% vs. 73.0% (P<0.05).
- Shorter swelling, healing, and downtime.
- Conclusion: Golden RF Microneedling + PRP is safe, effective, and superior to roller microneedling.
(2) PDRN / Salmon DNA
- Function: Anti-inflammatory + DNA repair, improves post-acne redness and sensitivity.
- Best For: Rosacea, post-laser hyperpigmentation (with low-energy microneedling).
(3) Exosomes
- Function: Modulate immune microenvironment, antioxidant, anti-photoaging.
- Advantages: Reduces UV-induced MMP (matrix metalloproteinase) expression, making it ideal for photoaged skin.
III. Functional Synergy (Based on Skin Concerns)
(1) Oil-Control & Anti-Acne
- Supramolecular Salicylic Acid (30%): Post-op immediate use dissolves oil plugs, antibacterial, lowers recurrence.
- Niacinamide Serum: Regulates sebaceous activity, minimizes pores (use after 72 hours).
(2) Whitening & Pigment Reduction
- L-Ascorbic Acid (Vit C) + Glutathione: Inhibit tyrosinase, reduce post-treatment pigmentation (avoid open wounds).
- Tranexamic Acid: Blocks melanin transfer, suitable for melasma patients.
(3) Anti-Aging & Filling
- Collagen Injections: Immediate filler effect for nasolabial folds, temples, while stimulating native collagen.
- Peptide Serums (e.g., Acetyl Hexapeptide-8): Stimulates fibroblast proliferation, enhances skin firmness.
IV. Professional Dressings (Immediate Post-Treatment Care)
(1) Collagen Cooling Masks
- Function: Physical cooling + micro-damage repair, reduces redness/swelling.
- Data: Redness reduction speed improved by 40% within 24 hours.
(2) Copper Peptide / Centella Asiatica Masks
- Function: Anti-inflammatory, angiogenesis promotion, accelerates wound healing.
- Best For: Deeper treatments (≥1.5 mm depth).
V. Golden RF Microneedling Combination Matrix
| Category | Representative Actives | Core Effects | Best Candidates |
|---|---|---|---|
| Immediate Repair | Hyaluronic Acid, Collagen | Hydration + barrier repair | Dry skin, high-energy procedures |
| Bioactive Agents | PRP, Exosomes, PDRN | Collagen regeneration + repair | Acne scars, sensitive skin, photoaging |
| Oil-Control/Acne | Salicylic Acid, Niacinamide | Antibacterial + sebum regulation | Oily/acne-prone, enlarged pores |
| Whitening/Pigment | Vitamin C, Tranexamic Acid | Melanin inhibition + brightening | Pigmentation-prone, melasma |
| Professional Dressing | Collagen sheets, Cooling | Cooling + healing acceleration | All post-microneedling patients |
VI. Key Considerations for Combination Use
(1) Timing Protocol
- Immediate (0–24h): HA, growth factors.
- After Healing (~72h): Functional actives (acids, whitening ingredients).
(2) Contraindications
- Active Infection: Avoid PRP, exosomes, other biologics.
- Sensitive Skin: Avoid strong acids; prioritize PDRN/collagen.
- Pigmentation Risk: Strict sun protection for 3 days, consider oral Vitamin C + Glutathione.
(3) Enhancement Tips
- Layering: First apply HA (hydration), then growth factors (repair).
- Device-Assisted: Post-treatment LED/yellow light for enhanced recovery.
Conclusion
Golden RF Microneedling, when paired with scientifically selected actives, enhances both immediate recovery and long-term outcomes. Whether targeting acne scars, pigmentation, sensitivity, or anti-aging, precise ingredient synergy + correct timing is the key to maximizing results while minimizing risks.
